How do animals keep track of where they are?

A stable sense of direction is the basis of many navigational strategies.

Recent work has uncovered circuits that maintain an internal compass, but the mechanisms by which this neural compass is constructed from sensory input in an ever-changing world are still mysterious.

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How do animals choose appropriate navigational strategies?

Depending on the environmental conditions, animals may not always have access to a reliable cue for orientation. We study what happens when and how insects switch strategies under conditions where their head direction system (their neural compass) fails.

Linking neural circuits to ethological relevant behavior

We study navigational strategies in both ants and flies (see below) in the context of dispersal and foraging. We study the behavior both in the laboratory, where we have precise control over the experimental conditions, and in the field, where we can more directly link our findings to the ecology of the animals.

We study two organisms with unique experimental advantages

In fruit flies (Drosophila melanogaster) we can use genetic tools and established calcium imaging techniques to monitor and perturb defined populations of neurons. Desert ants (Cataglyphis nodus) have exquisite and robust navigation behaviour, which has been characterised in a defined ethological context.

We compare these models across multiple axes: anatomical structure of circuits, behaviour and eventually physiology.

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Connecting circuits to behavior

Our goal is to understand how neural activity drives behavior. To get there, we combine the following techniques:

  • immersive virtual reality (VR) to simulate natural environments in the lab
  • in-vivo 2-photon calcium imaging in actively behaving flies (in VR)
  • high-resolution volume electron microscopy for connectomics
  • quantitative measurements of behavior and optogenetics

more about our VR system

Collaborations

  • Daniel Kronauer, Lindsey Lopes; The Rockefeller University, USA
  • Johannes Felsenberg, Dennis Goldschmidt; Friedrich Miescher Institute for Biomedical Research, Switzerland
  • Barry Dickson, Kai Feng; The University of Queensland, Queensland Brain Institute, Australia

News

The lab is growing

Özlem Gonulkirmaz-Cancalar, Johanna Wegmann and Yigit Yargili have joined the lab in November and January, respectively. Learn more about them and their projects here or on the zoology 2 website.

09.01.2025

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Our funding

Our research is currently funded through the the Emmy Noether Program of the German Research Council (DFG).